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Comparative Study
. 1991 Nov 15;280 ( Pt 1)(Pt 1):51-5.
doi: 10.1042/bj2800051.

Comparison of the domain-level organization of starch hydrolases and related enzymes

H M Jespersen  1 , E A MacGregor, M R Sierks, B Svensson
Affiliations
Comparative Study

Comparison of the domain-level organization of starch hydrolases and related enzymes

H M Jespersen et al. Biochem J. .

Abstract

Structure-prediction and hydrophobic-cluster analysis of several starch hydrolases and related enzymes indicated the organization of eleven domain types. Most enzymes possess a catalytic (beta/alpha)8-barrel and a smaller C-terminal domain as seen in crystal structures of alpha-amylase and cyclodextrin glucanotransferase. Some also have a starch-granule-binding domain. Enzymes breaking or forming endo-alpha-1,6 linkages contain domains N-terminal to the (beta/alpha)8-barrel.

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