Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Apr;39(4):273-7.
doi: 10.1111/j.1745-7270.2007.00276.x.

Inhibition of monosodium urate monohydrate-mediated hemolysis by vitamin E

Qiong Xie  1 , Shude Li, Weiyang Feng, Yongzhi Li, Yuanliang Wu, Wei Hu, Youguang Huang
Affiliations
Free article

Inhibition of monosodium urate monohydrate-mediated hemolysis by vitamin E

Qiong Xie et al. Acta Biochim Biophys Sin (Shanghai). 2007 Apr.
Free article

Abstract

Microcrystals of monosodium urate monohydrate (MSUM) induce cytolysis and hemolysis in erythrocytes. In this report, we studied the effect of vitamin E on MSUM-mediated hemolysis in human erythrocytes. Vitamin E significantly inhibited hemolysis induced by MSUM. The hydroxyl group in the chromanol ring of vitamin E is dispensable for protecting erythrocytes against hemolysis induced by MSUM, indicating that the inhibitory effect of vitamin E is not due to its antioxidant properties. However, both the chromanol ring and the isoprenoid side chain are important for vitamin E to suppress MSUM-induced hemolysis. Our current study suggests that vitamin E inhibits hemolysis induced by MSUM as a membrane stabilizer.

PubMed Disclaimer

Publication types