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. 2007 Jun 1;17(11):3010-3.
doi: 10.1016/j.bmcl.2007.03.055. Epub 2007 Mar 23.

Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors

Tao Guo  1 , Huizhong Gu, Doug W Hobbs, Laura L Rokosz, Tara M Stauffer, Biji Jacob, John W Clader
Affiliations

Design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors

Tao Guo et al. Bioorg Med Chem Lett. .

Abstract

Gamma-secretase is a key enzyme involved in the production of beta-amyloid peptides which are believed to play a critical role in the onset and progression of Alzheimer's disease (AD). As such, inhibition of gamma-secretase has been an attractive approach to AD therapy. In this paper, the design, synthesis, and evaluation of tetrahydroquinoline and pyrrolidine sulfonamide carbamates as gamma-secretase inhibitors are described.

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