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. 2007 Aug;88(2):504-6.
doi: 10.1016/j.fertnstert.2006.11.138. Epub 2007 Apr 6.

Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy

Aubert Agostini  1 , Karina Blanc, Isabelle Ronda, Fanny Romain, Mariane Capelle, Bernard Blanc
Affiliations

Prognostic value of human chorionic gonadotropin changes after methotrexate injection for ectopic pregnancy

Aubert Agostini et al. Fertil Steril. 2007 Aug.

Abstract

Because early prediction of clinical outcome (one or more injections or surgery) of methotrexate treatment of ectopic pregnancy could ease the intensity of follow-up and patient compliance required, we studied the relationship between the change in hCG levels after methotrexate injection and outcome in 129 consecutive patients. A 20% decline in hCG levels between days 1 and 4 during methotrexate treatment has a positive predictive value of 97%.

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