Comment
doi: 10.1016/j.devcel.2007.03.012.
The centrosome opens the way to mitosis
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- PMID: 17419985
- DOI: 10.1016/j.devcel.2007.03.012
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Comment
The centrosome opens the way to mitosis
Dev Cell.
2007 Apr.
Free article
Abstract
During mitosis, the interaction between chromosomes and microtubules requires nuclear envelope disassembly in prophase. Two articles in this issue of Developmental Cell show that centrosomes have a role in promoting nuclear envelope breakdown (Hachet et al., 2007; Portier et al., 2007). Surprisingly, the role of the centrosome in this process is independent of its role as a microtubule nucleation organelle. Instead, the centrosome seems to act as a spatial regulator for the activation of the Aurora A kinase.
Comment on
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A microtubule-independent role for centrosomes and aurora a in nuclear envelope breakdown.Dev Cell. 2007 Apr;12(4):515-29. doi: 10.1016/j.devcel.2007.01.019. Dev Cell. 2007. PMID: 17419991 Free PMC article.
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Centrosomes promote timely mitotic entry in C. elegans embryos.Dev Cell. 2007 Apr;12(4):531-41. doi: 10.1016/j.devcel.2007.02.015. Dev Cell. 2007. PMID: 17419992
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