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Randomized Controlled Trial
. 2007 Mar;4(1):3-7.
doi: 10.1111/j.1742-481X.2007.00300.x.

OASIS wound matrix versus Hyaloskin in the treatment of difficult-to-heal wounds of mixed arterial/venous aetiology

Marco Romanelli  1 , Valentina Dini, Mariastefania Bertone, Sabrina Barbanera, Cinzia Brilli
Affiliations
Randomized Controlled Trial

OASIS wound matrix versus Hyaloskin in the treatment of difficult-to-heal wounds of mixed arterial/venous aetiology

Marco Romanelli et al. Int Wound J. 2007 Mar.

Abstract

Mixed arterial/venous (A/V) ulcers are difficult to treat and slow to heal likely as a result of deficiencies in molecular and cellular elements in the wound bed. Recently, biomaterials have been developed that replace extracellular matrix (ECM) molecules and growth factors critical to the normal healing process. In this study, the effects of OASIS and Hyaloskin were evaluated to compare the effectiveness of these two ECM-based products in their ability to achieve complete wound healing of mixed A/V ulcers. After 16 weeks of treatment, patients in each group were evaluated on four criteria: complete wound healing, time to dressing change, pain and comfort. Complete wound closure was achieved in 82.6% of OASIS-treated ulcers compared with 46.2% of Hyaloskin-treated ulcers (P < 0.001). Statistically significant differences favouring the OASIS treatment group were also reported for time to dressing change (P < 0.05), pain (P < 0.05) and patient comfort (P < 0.01). Overall, OASIS was superior to Hyaloskin for the treatment of patients with mixed A/V ulcers, a population in which standard treatment options largely consist of moist wound dressings and compression therapy is typically not an option. OASIS is a useful and well-tolerated treatment for mixed A/V ulcers that has the potential to improve quality of life and reduce costs associated with standard of care.

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Figures

Figure 1
Figure 1
Percentage of patients achieving complete wound closure. Patients were evaluated after 16 weeks of treatment with either OASIS® or Hyaloskin®, and the percentage of ulcers that had completely healed was determined. Complete wound closure was achieved in 82·6% of OASIS®‐treated ulcers compared with 46·2% of Hyaloskin®‐treated ulcers (P < 0·001).
Figure 2
Figure 2
Mixed arterial/venous ulcer on lower leg after treatment with OASIS®. (A) At initial visit. (B) After application of OASIS®. (C) After 4 weeks of treatment. (D) The ulcer is completely healed after 6 weeks of OASIS® treatment.
See this image and copyright information in PMC

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