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Review
. 2007 Apr;7(2):146-53.
doi: 10.1007/s11892-007-0024-4.

The biology of RAGE and its ligands: uncovering mechanisms at the heart of diabetes and its complications

Shi Fang Yan  1 , Gaetano R Barile, Vivette D'Agati, Shi Du Yan, Ravichandran Ramasamy, Ann Marie Schmidt
Affiliations
Review

The biology of RAGE and its ligands: uncovering mechanisms at the heart of diabetes and its complications

Shi Fang Yan et al. Curr Diab Rep. 2007 Apr.

Abstract

The interaction of glucose-modified and inflammation-promoting ligands with the receptor for advanced glycation end products (RAGE) is emerging as a central mechanism contributing to the diverse complications of diabetes. These ligands, particularly in oligomeric form, bind to RAGE and transduce intracellular signals. The consequences of this interaction, as elucidated in cultured cells and animal models, include upregulation of inflammatory and tissue-degradative pathways. Pharmacologic antagonism of RAGE may hold promise for the treatment of diabetic complications.

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