Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance
- PMID: 1742648
- DOI: 10.1111/j.1365-2222.1991.tb00848.x
Double-blind cross-over trial of oral sodium cromoglycate in patients with irritable bowel syndrome due to food intolerance
Abstract
Twenty patients with irritable bowel syndrome due to food intolerance were randomized to either oral sodium cromoglycate or placebo in a double-blind cross-over trial. The study consisted of treatment with either sodium cromoglycate or placebo for 8 weeks, followed by the cross-over treatment for 8 further weeks. Patients were allowed to eat the offending foods during the study. Eighteen patients completed the study. Analysis of patients' diary card scores showed a statistically significant difference in favour of sodium cromoglycate. There was a long carry-over effect in the active-placebo order group. Therefore oral sodium cromoglycate seems to be a useful treatment in patients with irritable bowel syndrome and proven food intolerance.
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