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Comment
. 2007 Apr 12;356(15):1499-501.
doi: 10.1056/NEJMp078030.

Diabetes treatment--bridging the divide

Kristina I Rother  1
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Comment

Diabetes treatment--bridging the divide

Kristina I Rother. N Engl J Med. .
No abstract available

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Development of Diabetes
In the upper part of the diagram, a beta cell receives a primary insult. It is not known whether this insult is identical in type 1 diabetes and type 2 diabetes but leads to different responses because of variations in genetic susceptibility. The currently accepted view is that an immune-mediated insult leads to the primary beta-cell dysfunction in type 1 diabetes, whereas a different, unknown insult causes type 2 diabetes. Once injured, beta cells have a similar fate in the two types of diabetes. Glucotoxicity, oxidative stress, and cytotoxic cytokines lead to further damage, which eventually results in beta-cell death if the process is not countered by effective self-repair and therapeutic interventions.
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