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. 2007 Jun;7(6):1661-5.
doi: 10.1111/j.1600-6143.2007.01795.x. Epub 2007 Apr 8.

High expression of Tim-3 mRNA in urinary cells from kidney transplant recipients with acute rejection

P G Renesto  1 , V C Ponciano, M A Cenedeze, N O Saraiva Câmara, A Pacheco-Silva
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Free article

High expression of Tim-3 mRNA in urinary cells from kidney transplant recipients with acute rejection

P G Renesto et al. Am J Transplant. 2007 Jun.
Free article

Abstract

TIM-3 is a recently described molecule specifically expressed on Th1 differentiated T cells. We explored the usefulness of urinary mRNA profiles in the diagnosis of renal acute rejection (AR). Sixty urinary samples from renal transplant recipients simultaneously collected to allograft biopsy, (AR = 30 and No-AR =30), and 12 urinary samples from stable renal transplants were analyzed. Urinary mRNA encoding for TIM-3 and IFN-gamma were quantified using real time RT-PCR. TIM-3 mRNA was highly expressed in AR (559.19 +/- 644.41) compared to No-AR (3.78 +/- 7.20), and stable transplants (0.54 +/- 0.76), p < 0.001. To a lesser degree, IFN-gamma mRNA transcripts were also increased in AR (50.40 +/- 38.71), compared with No-AR (4.69 +/- 12.62), and stable transplants (0.38 +/- 0.44) p < 0.001. The highest expression of TIM-3 in AR makes it a promising noninvasive test for its diagnosis.

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