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Case Reports
. 2007 Oct;91(10):1379-81.
doi: 10.1136/bjo.2006.110346. Epub 2007 Apr 12.

Nuclear magnetic resonance analysis of emulsified silicone oil RMN-3 (Oxane HD)

Paul J Tomlins  1 , Malcolm G L Woodcock, Neil Spencer, Graham R Kirkby
Affiliations
Case Reports

Nuclear magnetic resonance analysis of emulsified silicone oil RMN-3 (Oxane HD)

Paul J Tomlins et al. Br J Ophthalmol. 2007 Oct.

Abstract

Background: Oxane HD is a mixture of 5700 cs silicone oil and RMN-3 (a partly fluorinated olefin), which has a specific gravity greater than water, thereby enabling endotamponade of inferior retinal breaks. Droplets of emulsified oil were found in the anterior chamber of two patients with complex retinal detachments who had been treated with Oxane HD. Samples removed from these two eyes were analysed in order to investigate the nature of the emulsified substance.

Methods: Samples were dissolved in CDCl3 and, if necessary, dried using magnesium sulphate. Nuclear magnetic resonance (NMR) was used to compare these samples with the unused commercial product.

Results: NMR analysis of the samples removed from the anterior segment of both eyes were mainly silicone oil with only trace amounts of RMN-3. Samples taken from different areas of an unused syringe of Oxane HD demonstrated varying concentrations of the RMN-3 compound within the silicone oil.

Conclusion: First, the mixture of RMN-3 and silicone oil is not homogenous either in vitro or in vivo. Second, emulsified oil found in the anterior chamber is composed almost entirely of silicone oil, containing only trace amounts of RMN-3.

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Conflict of interest statement

Competing interests: None.

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References

    1. Wolf S, Schon V, Meier P.et al Silicone oil‐RMN3 mixture (“heavy silicone oil”) as internal tamponade for complicated retinal detachment. Retina 200323335–342. - PubMed
    1. Rizzo S, Genovesi‐Ebert F, Belting C.et al A pilot study on the use of silicone oil‐RMN3 as heavier‐than‐water endotamponade agent. Graefes Arch Clin Exp Ophthalmol 20052431153–1157. - PubMed
    1. Wetterqvist C, Wong D, Williams R.et al Tamponade efficiency of perfluorohexyloctane and silicone oil solutions in a model eye chamber. Br J Ophthalmol 200488692–696. - PMC - PubMed
    1. Wong D, Van Meurs J C, Stappler T.et al A pilot study on the use of a perfluorohexyloctane/silicone oil solution as a heavier than water internal tamponade agent. Br J Ophthalmol 200589662–665. - PMC - PubMed
    1. Gungel H, Menceoglu Y, Yildiz B.et al Fourier transform infrared and 1 h nuclear magnetic resonance spectroscopic findings of silicone oil removed from eyes and the relationship of emulsification with retinotomy and glaucoma. Retina 200525332–338. - PubMed

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