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Editorial
. 2007 Apr 14;334(7597):756-7.
doi: 10.1136/bmj.39176.461227.80.

Composite and surrogate outcomes in randomised controlled trials

Nick Freemantle, Mel Calvert
Editorial

Composite and surrogate outcomes in randomised controlled trials

Nick Freemantle et al. BMJ. .

Abstract

Composite end points may mislead—and regulators allow it to happen

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Conflict of interest statement

Competing interests: NF has received funding for research, consultation fees, and travel expenses from several companies that manufacture treatments for diabetes and cardiovascular disease. MC has also received funding for research and travel expenses from several such companies.

Comment on

References

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    1. Freemantle N, Calvert M, Wood J, Eastaugh J, Griffin C. Composite outcomes in randomized trials—greater precision but with greater uncertainty? JAMA 2003;289:2554-9. - PubMed

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