doi: 10.1016/0378-1119(91)90302-r.
A split zinc-finger protein is required for normal yeast growth
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- PMID: 1743508
- DOI: 10.1016/0378-1119(91)90302-r
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A split zinc-finger protein is required for normal yeast growth
Gene.
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Abstract
We have identified a gene that, when present in multiple copies, partially inhibits nuclear protein localization in Saccharomyces cerevisiae. This gene encodes a protein that is a unique member of the Cys2His2 zinc-finger family of DNA-binding proteins. It is designated SFP1 for split finger protein because its two zinc-finger domains are separated from one another by 40 amino acids (aa) as opposed to the usual spacing of 7 or 8 aa for Cys2His2 proteins. Disruption of the SFP1 gene results in slow cell growth, with cells having multiple, nucleated buds.
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