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. 2007 May;39(5):593-5.
doi: 10.1038/ng2025. Epub 2007 Apr 15.

Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Idoya Lahortiga  1 , Kim De Keersmaecker, Pieter Van Vlierberghe, Carlos Graux, Barbara Cauwelier, Frederic Lambert, Nicole Mentens, H Berna Beverloo, Rob Pieters, Frank Speleman, Maria D Odero, Marijke Bauters, Guy Froyen, Peter Marynen, Peter Vandenberghe, Iwona Wlodarska, Jules P P Meijerink, Jan Cools
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Duplication of the MYB oncogene in T cell acute lymphoblastic leukemia

Idoya Lahortiga et al. Nat Genet. 2007 May.

Abstract

We identified a duplication of the MYB oncogene in 8.4% of individuals with T cell acute lymphoblastic leukemia (T-ALL) and in five T-ALL cell lines. The duplication is associated with a threefold increase in MYB expression, and knockdown of MYB expression initiates T cell differentiation. Our results identify duplication of MYB as an oncogenic event and suggest that MYB could be a therapeutic target in human T-ALL.

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