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. 2007 Mar-Apr;21(2):285-9.

(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

Hsu-Fung Lu  1 , Jia-You Liu, Shu-Ching Hsueh, Yi-Yuan Yang, Jai-Sing Yang, Tzu-Wei Tan, Lai-Fong Kok, Chi-Cheng Lu, Sheng-Huei Lan, Shan-Ying Wu, Shiu-Shin Liao, Siu-Wan Ip, Jing-Gung Chung
Affiliations
  • PMID: 17436578
Free article

(-)-Menthol inhibits WEHI-3 leukemia cells in vitro and in vivo

Hsu-Fung Lu et al. In Vivo. 2007 Mar-Apr.
Free article

Abstract

(-)-Menthol ([1-alpha]-5-methyl-2-[1-methylethyl]-cyclohexanol), is a widely used flavoring ingredient in mouthwash, foods, toothpaste and cigarettes. The studies reported here revealed that (-)-menthol induced cytotoxicity against murine leukemia WEHI-3 cells in vitro in a dose-dependent manner. The effects of (-)-menthol on WEHI-3 cells in vivo (BALBIc mice) were also examined, and it was observed that the Mac-3 and CD11b markers were decreased, indicating inhibition of differentiation of the precursor of macrophage and granulocyte. The weights of liver and spleen samples from mice treated with (-)-menthol were found to be decreased compared to untreated animals.

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