Hepatic prolyl hydroxylase activity in experimental cirrhosis
- PMID: 174370
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Hepatic prolyl hydroxylase activity in experimental cirrhosis
Acta Hepatogastroenterol (Stuttg).
1975 Dec.
Abstract
Hepatic collagen synthesis was studied during progressive fibrosis induced by carbon tetrachloride in male Sprague-Dawley rats by determination of prolyl hydroxylase activity and hydrocyproline levels along with morphological assessment of fibrosis. Cirrhosis was present after approximately 4 weeks treatment. Prolyl hydroxylase activity was increased significantly before fibrosis was apparent histologically or by hydroxyproline levels. The significance of this finding is discussed.
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