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. 2007 May 7;96(9):1404-8.
doi: 10.1038/sj.bjc.6603743. Epub 2007 Apr 17.

In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin

A Batistatou  1 , D Peschos, H Tsanou, A Charalabopoulos, Y Nakanishi, S Hirohashi, N J Agnantis, K Charalabopoulos
Affiliations

In breast carcinoma dysadherin expression is correlated with invasiveness but not with E-cadherin

A Batistatou et al. Br J Cancer. .

Abstract

Reduction/loss of E-cadherin is associated with the development and progression of many epithelial tumours. Dysadherin, recently characterised by members of our research team, has an anti-cell-cell adhesion function and downregulates E-cadherin in a post-transcriptional manner. The aim of the present study was to study the role of dysadherin in breast cancer progression, in association with the E-cadherin expression and the histological type. We have selected ductal carcinoma, which is by far the most common type and lobular carcinoma, which has a distinctive microscopic appearance. Dysadherin and E-cadherin expression was examined immunohistochemically in 70 invasive ductal carcinomas, no special type (NST), and 30 invasive lobular carcinomas, with their adjacent in situ components. In ductal as well as in lobular carcinoma dysadherin was expressed only in the invasive and not in the in situ component, and this expression was independent of the E-cadherin expression. Specifically, all 10 (100%) Grade 1, 37 out of 45(82.2%) Grade 2 and six out of 15 (40%) Grade 3 invasive ductal carcinomas showed preserved E-cadherin expression, while 'positive dysadherin expression' was found in six out of 10 (60%) Grade 1, 34 out of 45(75.5%) Grade 2 and all 15 (100%) Grade 3 neoplasms. None of the 30 infiltrating lobular carcinomas showed preserved E-cadherin expression, while all the 30 infiltrating lobular carcinomas exhibited 'positive dysadherin expression'. Dysadherin may play an important role in breast cancer progression by promoting invasion and, particularly in lobular carcinomas, it might also be used as a marker of invasion.

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Figures

Figure 1
Figure 1
A case of invasive ductal carcinoma, grade II, with adjacent in situ component. (A) E-cadherin expression is significantly reduced in invasive ductal carcinoma (DABX400). (B) Membranous expression of E-cadherin is retained in the adjacent in situ component (DABX400). (C) Strong, membranous expression of dysadherin is evident in invasive ductal carcinoma (DABX400). (D) Dysadherin is not expressed in the adjacent in situ component (DABX400).
Figure 2
Figure 2
A case of invasive lobular carcinoma, with adjacent in situ component. (A) E-cadherin expression is lost in invasive lobular carcinoma (DABX400). (B) E-cadherin expression is lost in the adjacent in situ component (DABX400). (C) Membranous expression of dysadherin is evident in invasive lobular carcinoma, (DABX400). (D) Dysadherin is not expressed in the adjacent in situ component, in contrast with the infiltrating tumour (DABX400).
See this image and copyright information in PMC

References

    1. Aoki S, Shimamura T, Shibata T, Nakanishi Y, Moriya Y, Sato Y, Kitajima M, Sakamoto M, Hirohashi S (2003) Prognostic significance of dysadherin expression in advanced colorectal carcinoma. Br J Cancer 88: 726–732 - PMC - PubMed
    1. Batistatou A, Charalabopoulos AK, Scopa CD, Nakanishi Y, Kappas A, Hirohashi S, Agnantis NJ, Charalabopoulos K (2006) Expression patterns of dysadherin and E- cadherin in lymph node metastases of colorectal carcinoma. Virchows Arch 448: 763–777 - PubMed
    1. Batistatou A, Scopa CD, Ravazoula P, Nakanishi Y, Peschos D, Agnantis NJ, Hirohashi S, Charalabopoulos KA (2005) Involvement of dysadherin and E-cadherin in the development of testicular tumors. Br J Cancer 93: 1382–1387 - PMC - PubMed
    1. Becker KF, Atkinson MJ, Reich U, Becker I, Nekarda H, Siewert JR, Hofler H (1994) E- cadherin gene mutations provide clues to diffuse type gastric carcinomas. Cancer Res 54: 3845–3852 - PubMed
    1. Chang HW, Chow V, Lam KY, Wei WI, Yuen A (2002) Loss of E-cadherin expression resulting from promoter hypermethylation in oral tongue carcinoma and its prognostic significance. Cancer 94: 386–392 - PubMed