Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 2007 Jul;51(7):2346-50.
doi: 10.1128/AAC.01344-06. Epub 2007 Apr 16.

Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis

Valter F de Andrade-Neto  1 , Tito da Silva, Lucia M Xavier Lopes, Virgílio E do Rosário, Fernando de Pilla Varotti, Antoniana U Krettli
Affiliations
Comparative Study

Antiplasmodial activity of aryltetralone lignans from Holostylis reniformis

Valter F de Andrade-Neto et al. Antimicrob Agents Chemother. 2007 Jul.

Abstract

Extracts from Holostylis reniformis were tested in vivo against Plasmodium berghei and in vitro against a chloroquine-resistant strain of Plasmodium falciparum. The hexane extract of the roots was the most active, causing 67% reduction of parasitemia in vivo. From this extract, six lignans, including a new (7'R,8S,8'S)-3',4'-methylenedioxy-4,5-dimethoxy-2,7'-cyclolignan-7-one, were isolated and tested in vitro against P. falciparum. The three most active lignans showed 50% inhibitor concentrations of < or =0.32 microM. An evaluation of minimum lethal dose (30%) values showed low toxicity for these lignans in a hepatic cell line (Hep G2A16). Therefore, these compounds are potential candidates for the development of antimalarial drugs.

PubMed Disclaimer

Figures

FIG. 1.
FIG. 1.
Bioassayed lignans from H. reniformis.
FIG. 2.
FIG. 2.
Selected nuclear Overhauser enhancement interactions and conformation for lignan 6.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Andrade-Neto, V. F., M. G. L. Brandão, F. Q. Oliveira, V. W. D. Casali, B. Njaine, M. G. Zalis, L. A. Oliveira, and A. U. Krettli. 2004. Antimalarial activity of Bidens pilosa L. (Asteraceae) ethanol extracts from wild plants collected in various localities of plants cultivated in humus soil. Phytother. Res. 18634-639. - PubMed
    1. Apers, S., A. Vlietinck, and L. Pieters. 2003. Lignans and neolignans as lead compounds. Phytochem. Rev. 2201-217.
    1. Carvalho, L. H., M. G. L. Brandão, D. Santos-Filho, J. L. C. Lopes, and A. U. Krettli. 1991. Antimalarial activity of crude extracts from Brazilian plants. Studied in vivo in Plasmodium berghei-infected mice and in vitro against Plasmodium falciparum in culture. Braz. J. Med. Biol. Res. 241113-1123. - PubMed
    1. da Silva, T., A. U. Krettli, V. F. de Andrade-Neto, and L. M. X. Lopes. 2005. Lignans, and particularly aryltetralone lignans, extracts containing them, processes for obtaining the extracts and the lignans, and use of the lignans or the extracts in pharmaceutical compositions for treating or preventing malaria. Rev. Prop. Ind. 17951774-1786.
    1. da Silva, T., and L. M. X. Lopes. 2004. Aryltetralone lignans and 7,8-seco-lignans from Holostylis reniformis. Phytochemistry 65751-759. - PubMed

Publication types

MeSH terms

LinkOut - more resources