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. 2007 Jun;51(6):2257-9.
doi: 10.1128/AAC.00095-07. Epub 2007 Apr 16.

Paradoxical effect of Echinocandins across Candida species in vitro: evidence for echinocandin-specific and candida species-related differences

Georgios Chamilos  1 , Russell E Lewis, Nathaniel Albert, Dimitrios P Kontoyiannis
Affiliations

Paradoxical effect of Echinocandins across Candida species in vitro: evidence for echinocandin-specific and candida species-related differences

Georgios Chamilos et al. Antimicrob Agents Chemother. 2007 Jun.

Abstract

Paradoxical growth of some Candida isolates occurs at concentrations above the MIC for echinocandins. In 60 Candida bloodstream isolates from cancer patients (20 C. albicans isolates and 10 isolates each of C. parapsilosis, C. tropicalis, C. krusei, and C. glabrata), paradoxical growth was more frequent with caspofungin than micafungin or anidulafungin, was unrelated to MIC, and was strikingly absent in C. glabrata isolates.

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Figures

FIG. 1.
FIG. 1.
Association of caspofungin (CAS), micafungin (MICA), and anidulafungin (ANID) MICs with the presence of paradoxical effect. Note that the median MIC of caspofungin was comparable between the Candida isolates exhibiting paradoxical growth and those in which the phenomenon was absent. In contrast, paradoxical growth was seen almost exclusively in C. krusei and C. tropicalis isolates exhibiting significantly lower MICs than the median MIC of micafungin and anidulafungin for the corresponding species. *, MIC for C. krusei and C. tropicalis isolates with paradoxical effect compared with the corresponding isolates without paradoxical effect (P < 0.001). All other comparisons were not significant. +, presence of paradoxical effect; −, absence of paradoxical effect.
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