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Comment
. 2007 May;129(5):379-83.
doi: 10.1085/jgp.200709786. Epub 2007 Apr 16.

Calcium channels are models of self-control

Kathleen Dunlap  1
Affiliations
Comment

Calcium channels are models of self-control

Kathleen Dunlap. J Gen Physiol. 2007 May.
No abstract available

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Figures

Figure 1.
Figure 1.
Calcium/calmodulin-mediated regulation of Cav2.1 calcium channel. Calmodulin (Swiss Army knife) is shown interacting with the IQ domain in the carboxy-terminal tail of a Cav2.1, voltage-gated calcium channel (light green). When calmodulin binds calcium ions (yellow circles), its two functional lobes differentially activate a rapid mechanism (red) that facilitates current flow and a slower mechanism (blue) that inhibits current flow by changing the probability of channel opening. With apologies to Reuben Garrett L. Goldberg.
Figure 2.
Figure 2.
Lobe specificity of calmodulin. Summary of the effects of the N and C lobes of calmodulin on the voltage-gated calcium channel types noted in the leftmost column. CDI (calcium-dependent inactivation); CDF (calcium-dependent facilitation); - - - (no effect). Crystal structure of chicken calmodulin complexed with four calcium ions (yellow spheres) shown at top (from Rupp et al., 1996; Protein Data Bank entry 1UP5). Adapted from Liang et al., 2003.
See this image and copyright information in PMC

Comment on

References

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