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Comparative Study
. 1991 Sep;15(5):303-10.
doi: 10.1007/BF00128948.

In vitro viability of choroidal melanomata following pre-enucleation irradiation

U Chakravarthy  1 , L Frew, T A Gardiner, D B Archer
Affiliations
Comparative Study

In vitro viability of choroidal melanomata following pre-enucleation irradiation

U Chakravarthy et al. Int Ophthalmol. 1991 Sep.

Abstract

In a group of eighteen patients with uveal melanomas, seven underwent low-dose pre-enucleation irradiation of approximately 2000 cGy. All the tumours were propagated in tissue culture and the growth characteristics of tumour cells from irradiated eyes were compared with tumour cells from non-irradiated eyes. Cultures were observed with phase-contrast microscopy, and radioactive thymidine labelling was used to study cell turnover. Although tissue samples from peripheral areas of irradiated tumours produced a mixture of viable and non-viable cells, with reduced ability to attach to substrate, central regions of irradiated tumours contained viable cells which propagated freely in tissue culture.

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References

    1. Nature. 1964 Jan 18;201:272-3 - PubMed
    1. Br J Cancer. 1982 Jan;45(1):10-6 - PubMed
    1. Br J Radiol. 1953 Dec;26(312):638-48 - PubMed
    1. Can J Ophthalmol. 1989 Feb;24(1):10-4 - PubMed
    1. Am J Ophthalmol. 1988 Jul 15;106(1):21-6 - PubMed

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