Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991;117(6):597-602.
doi: 10.1007/BF01613295.

Effects of radiation fractionation on four squamous cell carcinoma lines with dissimilar inherent radiation sensitivity

K Pekkola-Heino  1 , J Kulmala, P Klemi, T Lakkala, K Aitasalo, H Joensuu, R Grenman
Affiliations

Effects of radiation fractionation on four squamous cell carcinoma lines with dissimilar inherent radiation sensitivity

K Pekkola-Heino et al. J Cancer Res Clin Oncol. 1991.

Abstract

The effect of radiation fractionation was investigated using a new 96-well-plate clonogenic assay in four squamous cell carcinoma lines. Earlier experiments had shown that two of the cell lines (UT-SCC-1A and UM-SCC-14A) were inherently relatively sensitive to irradiation, and two (UM-SCC-1 and UM-SCV-1A) relatively resistant. All of the four carcinomas from which the cell lines were established had poor clinical outcome. The radiation doses were given as a single exposure, or split into two or three equal fractions with a 24-h interval. The two inherently sensitive cell lines showed enhanced survival after radiation fractionation as compared with a single dose, whereas the resistant cell lines did not. The result suggests that both the inherent resistance of cancer cells to irradiation and the repair of sublethal radiation damage may lead to treatment failure, and that shortening of the total irradiation time may overcome cancer cell recovery between fractions in some, but not in all carcinomas.

PubMed Disclaimer

References

    1. Baker F, Spitzer G, Ajani JA, Brock WA, Lukeman J, Pathak S, Tomasovic B, Thielvoldt D, Williams M, Vines C, Tofilon P (1986) Drug and radiation sensitivity measurements of successful primary monolayer culturing of human tumor cells using cell-adhesive matrix and supplemented medium. Cancer Res 46:1263–1274 - PubMed
    1. Brock WA, Baker FL, Tofilon PJ (1989) Tumor cell sensitivities to drugs and radiation. In: Chapman JD, Peters LJ, Withers HR (eds) Prediction of tumor treatment response. Pergamon, Oxford, pp 139–155
    1. Byhardt RW, Greenberg M, Cox JD (1977) Local control of squamous carcinoma of oral cavity and oropharynx with 3 vs 5 treatment fractions per week. Int J Radiat Oncol Biol Phys 2:415–420 - PubMed
    1. Deschavanne PJ, Fertil B, Chavaudra N, Malaise EP (1990) The relationship between radiosensitivity and repair of potentially lethal damage in human tumor cell lines with implications for radioresponsiveness. Radiat Res 122:29–37 - PubMed
    1. Elkind MM, Sutton H (1960) Radiation response of mammalian cells grown in culture: I. Repair of X-ray damage in surviving Chinese hamster cells. Radiat Res 13:556–593 - PubMed

Publication types

LinkOut - more resources