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Comparative Study
. 1991;161(5):543-7.
doi: 10.1007/BF00257911.

Differences in the hypoxic contraction of small isolated pulmonary arteries of cat and rabbit

P Bonnet  1 , J A Argibay, E White, D Garnier
Affiliations
Comparative Study

Differences in the hypoxic contraction of small isolated pulmonary arteries of cat and rabbit

P Bonnet et al. J Comp Physiol B. 1991.

Abstract

In small (less than 300 microns diameter) pulmonary arterial (PA) rings isolated from the cat, hypoxia induced a transient contraction (250 +/- 120 mg, n = 7), whereas in rings of rabbit PA of the same size, hypoxia had no significant effect (n = 19). Precontraction by 40 mmol KCl.1(-1), noradrenaline (NA) 10(-6) mol.1(-1), or histamine (His 10(-5) mol.1(-1)) did not modify this difference between the two species and did not potentiate the hypoxic contraction of small rings of the cat PA. Large rabbit pulmonary arterial segments (300-2000 microns) exhibited no response to hypoxia before precontraction (n = 15). In the presence of procaine (2%) rabbit PA rings (n = 6, small) exhibited no hypoxic contraction. These results in vitro reflect previous in vivo observations.

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