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Case Reports
. 2007 Jun;45(6):2068-71.
doi: 10.1128/JCM.00320-07. Epub 2007 Apr 18.

Fatal echovirus 18 leukoencephalitis in a child

Delphine Brunel  1 , Jérôme Jacques, Jacques Motte, Laurent Andréoletti
Affiliations
Case Reports

Fatal echovirus 18 leukoencephalitis in a child

Delphine Brunel et al. J Clin Microbiol. 2007 Jun.

Abstract

Rare cases of leukoencephalitis have been reported in infants with documented enterovirus (EV) central nervous system (CNS) infections. A case of fatal encephalitis with white matter lesions caused by echovirus 18 is described, and it highlights the role of EV CNS infection as a potential cause of leukoencephalitis in infants.

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Figures

FIG. 1.
FIG. 1.
Brain MRI studies (axial, T2 weighted). (A and C) Axial, T2-weighted, diffuse, hyperintense signals with particular predominance in the periventricular and subcortical white matter of both cerebral hemispheres on day 2 after symptom onset (arrows). (B and D) Seven days after symptom onset, an axial, T2-weighted study revealed the extension of diffuse, hyperintense signals into the subcortical and deep white matter of both cerebral hemispheres (arrows).
FIG. 2.
FIG. 2.
Comparison of the VP1 gene sequences of the two EV-18 strains isolated from samples from the patient described in this case report with those obtained from other, cocirculating, EV strains isolated from the throats of infants with classical aseptic meningitis during the same epidemic season.
See this image and copyright information in PMC

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