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. 2007 Apr 13;2(4):e18.
doi: 10.1371/journal.pctr.0020018.

When and how can endpoints be changed after initiation of a randomized clinical trial?

Scott Evans  1
Affiliations

When and how can endpoints be changed after initiation of a randomized clinical trial?

Scott Evans. PLoS Clin Trials. .
No abstract available

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Conflict of interest statement

Competing Interests: The author is a member of the PLoS Clinical Trials Editorial Board and has interacted with PLoS Clinical Trials personnel in his capacity as an Editor.

References

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    1. Skyler JS. PROactive results overstated and misleading. DOC News. 2005;2:4.
    1. Charbonnel B, Dormandy J, Erdmann E, Massi-Benedetti M, Skene A. The prospective pioglitazone clinical trial in macrovascular events (PROactive): Can pioglitazone reduce cardiovascular events in diabetes? Study design and baseline characteristics of 5238 patients. Diabetes Care. 2004;27:1647–1653. - PubMed
    1. Dormandy J, Charbonnel B, Eckland D, Erdmann E, Massi-Benedetti M, et al. PROactive study. Lancet. 2006;367:982.