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. 2007 May 10;9(10):1863-6.
doi: 10.1021/ol070195g. Epub 2007 Apr 20.

New electrophilic difluoromethylating reagent

G K Surya Prakash  1 , Csaba Weber, Sujith Chacko, George A Olah
Affiliations

New electrophilic difluoromethylating reagent

G K Surya Prakash et al. Org Lett. .

Abstract

A new electrophilic difluoromethylating reagent has been developed. The S-(difluoromethyl)diarylsulfonium tetrafluoroborate has been shown to be effective for the introduction of an electrophilic difluoromethyl group into the following nucleophiles: sulfonic acids, tertiary amines, imidazole derivatives, and phosphines. The reagent failed to transfer the difluoromethyl group to phenols, carbon nucleophiles, and primary and secondary amines.

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