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Review
. 2007:27:389-414.
doi: 10.1146/annurev.nutr.26.061505.111329.

Taste receptor genes

Alexander A Bachmanov  1 , Gary K Beauchamp
Affiliations
Review

Taste receptor genes

Alexander A Bachmanov et al. Annu Rev Nutr. 2007.

Abstract

In the past several years, tremendous progress has been achieved with the discovery and characterization of vertebrate taste receptors from the T1R and T2R families, which are involved in recognition of bitter, sweet, and umami taste stimuli. Individual differences in taste, at least in some cases, can be attributed to allelic variants of the T1R and T2R genes. Progress with understanding how T1R and T2R receptors interact with taste stimuli and with identifying their patterns of expression in taste cells sheds light on coding of taste information by the nervous system. Candidate mechanisms for detection of salts, acids, fat, complex carbohydrates, and water have also been proposed, but further studies are needed to prove their identity.

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Figures

Figure 1
Figure 1
Conformation of T1R and T2R proteins. Both T1R and T2R proteins are predicted to have seven transmembrane domains. The T1R proteins consist of ~850 amino acids and have a large extracellular N-terminus. The T2R proteins consist of ~300–330 amino acids and have a short extracellular N-terminus.
See this image and copyright information in PMC

References

    1. GPCRDB. Information system for G protein-coupled receptors (GPCRs) Nijmegen, Netherlands: GPCRDB Inform. Syst; 2007. [Accessed March 27]. http://www.gpcr.org/7tm/
    1. Human Genome Database. Baltimore, MD: GDB; 2007. [Accessed March 27]. http://www.gdb.org.
    1. The Human Genome Organisation (HUGO) Gene Nomenclature Committee. London: HUGO; 2007. [Accessed March 27]. http://www.gene.ucl.ac.uk/nomenclature/
    1. Mouse Genome Informatics. Bar Harbor, ME: Jackson Lab; 2007. [Accessed March 27]. http://www.informatics.jax.org.
    1. Rules for Nomenclature of Genes, Genetic Markers, Alleles, and Mutations in Mouse and Rat. Bar Harbor, ME: Jackson Lab; 2007. [Accessed March 27]. http://www.informatics.jax.org/mgihome/nomen/gene.shtml.

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