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Review
. 2007 Jun;7(3):237-43.
doi: 10.1016/j.coph.2006.11.014. Epub 2007 Apr 18.

Adenovirus infections and lung disease

Shizu Hayashi  1 , James C Hogg
Affiliations
Review

Adenovirus infections and lung disease

Shizu Hayashi et al. Curr Opin Pharmacol. 2007 Jun.

Abstract

Adenovirus, particularly its E1A protein, has been investigated in the pathogenesis of chronic obstructive pulmonary disease (COPD). High levels of E1A DNA were found in the lungs of COPD patients, where its expression increased with disease severity. In lung epithelial cells, E1A increased intercellular adhesion molecule-1 and interleukin-8 expression, as well as nuclear factor-kappaB activation, in response to inflammatory stimuli. In addition to regulating the mediators that promote emphysema, E1A upregulates transforming growth factor-beta1 expression in bronchiolar epithelial cells and transforms lung epithelial cells to express mesenchymal markers. These results support its additional role in the airway remodeling process reported in COPD.

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Figures

Figure 1
Figure 1
Respiratory consequences of adenovirus infections.
Figure 2
Figure 2
Histological preparations of adenovirus pneumonia in a pediatric patient. (a) Section stained with hematoxylin-eosin showing bronchial lumen partially filled with an organizing inflammatory exudate (*). (b)In situ hybridization with an adenoviurs probe of a serial section of the lung in (a) showing virus-positive epithelial cells lining the bronchioles (arrowheads), as well as in the parenchyma (arrows). Original magnification: x250. Reproduced with permission from [15].
See this image and copyright information in PMC

References

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    2. Although this is mainly a review of adenovirus as a vector for gene therapy, the readers are directed to its introductory sections that provide a concise summary of the history, epidemiology, structure and life-cycle of the virus, details of which could not be presented in the current review on lung diseases. The review includes new findings on cellular receptors of the virus, endocystosis and viral packaging.

    1. Horwitz M.S. Function of adenovirus E3 proteins and their interactions with immunoregulatory cell proteins. J Gene Med. 2004;6(Suppl 1):S172–S183. - PubMed

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