Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 1991 Nov;84(11):650-1.
doi: 10.1177/014107689108401107.

Low dose botulinum toxin in spasmodic torticollis

D F D'Costa  1 , R J Abbott
Affiliations

Low dose botulinum toxin in spasmodic torticollis

D F D'Costa et al. J R Soc Med. 1991 Nov.

Abstract

Botulinum toxin has been successfully used to treat spasmodic torticollis. The optimum dosage is not clear and the recommended doses in the United Kingdom are 20-25 ng. We have used much lower doses (average 13 ng) without loss of efficacy and accompanied by a reduction in side effects. We treated 12 patients (eight women and four men) with a mean duration of torticollis of 4 years. Eleven of the 12 patients (91%) showed an improvement in total scores for pain and degree of head movement. The benefits appeared a week after treatment and lasted for 3 months. Side effects were minimal and transient. Our experience suggests low doses of the toxin may be equally efficacious.

PubMed Disclaimer

Comment in

References

    1. Lancet. 1986 Aug 2;2(8501):245-7 - PubMed
    1. Neurology. 1989 Jan;39(1):80-4 - PubMed
    1. J Neurol Neurosurg Psychiatry. 1988 Jul;51(7):920-3 - PubMed
    1. Muscle Nerve. 1987 Jul-Aug;10(6):552-5 - PubMed
    1. Arch Ophthalmol. 1985 Mar;103(3):347-50 - PubMed

Substances