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. 2007 Dec;13(8):480-2.
doi: 10.1016/j.parkreldis.2007.02.002. Epub 2007 Apr 19.

CSF biomarker profiles do not differentiate between the cerebellar and parkinsonian phenotypes of multiple system atrophy

W F Abdo  1 , B P C van de Warrenburg, H P H Kremer, B R Bloem, M M Verbeek
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CSF biomarker profiles do not differentiate between the cerebellar and parkinsonian phenotypes of multiple system atrophy

W F Abdo et al. Parkinsonism Relat Disord. 2007 Dec.

Abstract

Background: Multiple system atrophy (MSA) can clinically be divided into the cerebellar (MSA-C) and the parkinsonian (MSA-P) variants. It is unknown whether the variation in clinical expression is also reflected by a different underlying neurochemical profile.

Methods: We analyzed brain specific proteins and neurotransmitter metabolites in cerebrospinal fluid (CSF) of 26 patients with MSA-C and 19 with MSA-P.

Results: No differences were found between MSA-C and MSA-P.

Conclusion: Our results suggest that the clinical and in part pathological distinction between the two clinical MSA phenotypes is not reflected by the neurochemical composition of CSF.

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