miR-1-2 gets to the heart of the matter
- PMID: 17448987
- DOI: 10.1016/j.cell.2007.04.008
miR-1-2 gets to the heart of the matter
Abstract
Although many microRNAs (miRNAs) and their targets have been identified, the importance of miRNAs in vivo is still unclear. In this issue, Zhao et al. (2007) generate mice deficient in a cardiac-specific miRNA, miR-1-2, and reveal that this microRNA plays a crucial role in heart development and physiology.
Comment on
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Dysregulation of cardiogenesis, cardiac conduction, and cell cycle in mice lacking miRNA-1-2.Cell. 2007 Apr 20;129(2):303-17. doi: 10.1016/j.cell.2007.03.030. Epub 2007 Mar 29. Cell. 2007. PMID: 17397913
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