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Review
. 2007 Apr 20;129(2):251-62.
doi: 10.1016/j.cell.2007.04.001.

The hormonal control of food intake

Anthony P Coll  1 , I Sadaf Farooqi, Stephen O'Rahilly
Affiliations
Review

The hormonal control of food intake

Anthony P Coll et al. Cell. .

Abstract

Numerous circulating peptides and steroids produced in the body influence appetite through their actions on the hypothalamus, the brain stem, and the autonomic nervous system. These hormones come from three major sites-fat cells, the gastrointestinal tract, and the pancreas. In this Review we provide a synthesis of recent evidence concerning the actions of these hormones on food intake.

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Figures

Figure 1
Figure 1
Control of Food Intake by the Hypothalamic Leptin-Melanocortin Pathway The hypothalamus receives and integrates neural, metabolic, and hormonal signals to regulate energy homeostasis. In particular, the adipocyte-derived hormone leptin and the melanocortin pathway have a critical role in the control of food intake. AgRP, Agouti-related protein; Arc, arcuate nucleus; MC4R, melanocortin 4 receptor; POMC, pro-opiomelanocortin; PVN, paraventricular nucleus.
Figure 2
Figure 2
Hormones from the Gut and Endocrine Organs Affect Food Intake Hormonal signals derived from the gut and classical endocrine organs, such as the pancreas, thyroid, and adrenal glands act in synergy to effect changes in feeding behavior. CCK, cholecystokinin; OXM, oxyntomodulin; GLP-1, glucagon-like peptide 1; PYY3–36, peptide YY3–36.
See this image and copyright information in PMC

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