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. 2007 Jul;65(7):818-26.
doi: 10.1016/j.apradiso.2007.02.004. Epub 2007 Mar 6.

Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18

Christina Hultsch  1 , Mathias Berndt, Ralf Bergmann, Frank Wuest
Affiliations

Radiolabeling of multimeric neurotensin(8-13) analogs with the short-lived positron emitter fluorine-18

Christina Hultsch et al. Appl Radiat Isot. 2007 Jul.

Abstract

Three methods for (18)F-labeling of dimeric and tetrameric neurotensin(8-13) derivatives were evaluated with respect to the labeling yield and the required peptide amounts. Labeling using N-succinimidyl-4-[(18)F]fluorobenzoate ([(18)F]SFB) gave low radiochemical yield for the dimeric peptides. Coupling of the tetramer with [(18)F]SFB was not successful. High yields were obtained for labeling of the aminooxy-functionalized neurotensin(8-13) dimer using 4-[(18)F]fluorobenzaldehyde ([(18)F]FBA) whilst coupling of the corresponding tetramer gave only low yields. Labeling of sulfydryl-functionalized neurotensin(8-13) derivatives using the maleinimide 4-[(18)F]fluorobenzaldehyde-O-[6-(2,5-dioxo-2,5-dihydro-pyrrol-1-yl)-hexyl]-oxime ([(18)F]FBAM) resulted in high radiochemical yields for both, the dimer and the tetramer. Therefore, [(18)F]FBAM seems to be the most suitable (18)F-labeling agent for multivalent neurotensin(8-13) derivatives.

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