Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2007 Jun 4;96(11):1750-4.
doi: 10.1038/sj.bjc.6603759. Epub 2007 Apr 24.

Sensitivity of latex agglutination faecal occult blood test in the Florence District population-based colorectal cancer screening programme

G Castiglione  1 , C B Visioli, S Ciatto, G Grazzini, A G Bonanomi, T Rubeca, P Mantellini, M Zappa
Affiliations

Sensitivity of latex agglutination faecal occult blood test in the Florence District population-based colorectal cancer screening programme

G Castiglione et al. Br J Cancer. .

Abstract

We evaluated the sensitivity for colorectal cancer (CRC) of the latex agglutination test (LAT), an immunochemical test routinely used in the Florence District screening programme since 2000. Sensitivity was calculated by the proportional interval cancer incidence method in a population of 27,503 consecutive subjects screened in 2000-2002, interval cancers being identified by linkage to the Tuscany Cancer Registry files. Sensitivity was calculated overall and by gender, age, time since last negative LAT, CRC site, and rank of screening. Overall 1- and 2-year sensitivity estimates were 80.7 and 71.5%, respectively, suggesting that faecal occult blood testing screening sensitivity may be suboptimal due to testing or programme quality problems. Increasing screening sensitivity might be achieved if the detection rate of advanced adenomas could be increased without unacceptable loss in specificity.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Allison JE, Tekama IS, Ransom LJ, Adrian AL (1996) A comparison of fecal occult-blood tests for colorectal-cancer screening. N Engl J Med 334: 155–159 - PubMed
    1. Castiglione G, Zappa M, Grazzini G, Sani C, Mazzotta A, Mantellini P, Ciatto S (1997) Cost analysis in a population based screening programme for colorectal cancer: comparison of immunochemical and guaiac faecal occult blood testing. J Med Screen 4: 142–146 - PubMed
    1. Castiglione G, Zappa M., Grazzini G, Rubeca T, Turco P, Sani C, Ciatto S (2000) Screening for colorectal cancer by faecal occult blood test: comparison of immunochemical tests. J Med Screen 7: 35–37 - PubMed
    1. Church TR, Ederer F, Mandel JS (1997) Fecal occult blood screening in the Minnesota study: sensitivity of the screening test. J Natl Cancer Inst 89: 1440–1448 - PubMed
    1. Clayton D, Hills M (1993) Statistical models in epidemiology. Oxford University Press: Oxford

Publication types