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Case Reports
. 2007 May;27(5):315-6.
doi: 10.1038/sj.jp.7211674.

An unusual case of retinopathy of prematurity

K Mandal  1 , J A Drury, D I Clark
Affiliations
Case Reports

An unusual case of retinopathy of prematurity

K Mandal et al. J Perinatol. 2007 May.

Abstract

Aims: Stage 3 retinopathy of prematurity (ROP) usually develops in the very small babies. An infant born at 30 (2) weeks' gestation and of birth weight 2102 g was found to have stage 3 ROP bilaterally. The unusual severity of the disease in a child of birth weight >2000 g prompted further investigation. The aim was to look for any genetic causes for ROP.

Methods: Chromosomal analysis followed by vasculoendothelial growth factor (VEGF) analysis.

Results: Unbalanced translocation 18p (monosomy) and 6p (trisomy). Overexpression of VEGF.

Conclusions: Overexpression of VEGF contributed to the unusual severity of ROP in this relatively large baby.

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