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. 2007 May 24;9(11):2159-62.
doi: 10.1021/ol070674f. Epub 2007 Apr 25.

Synthesis of pyroglutamic acid derivatives via double michael reactions of alkynones

Myriam Scansetti  1 , Xiangping Hu, Benjamin P McDermott, Hon Wai Lam
Affiliations

Synthesis of pyroglutamic acid derivatives via double michael reactions of alkynones

Myriam Scansetti et al. Org Lett. .

Abstract

In the presence of substoichiometric quantities of potassium tert-butoxide and an additional metal salt, amide-tethered diacids undergo double Michael reactions with alkynones to provide highly functionalized pyroglutamic acid derivatives. The metal salt was found to play an important role in improving the diastereoselectivities of the reactions.

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