doi: 10.1021/ol070788r.
Epub 2007 Apr 25.
Tandem gold(I)-catalyzed cyclization/electrophilic cyclopropanation of vinyl allenes
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- PMID: 17455944
- DOI: 10.1021/ol070788r
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Tandem gold(I)-catalyzed cyclization/electrophilic cyclopropanation of vinyl allenes
Org Lett.
.
Abstract
We have developed an expedient method for the synthesis of polycyclic compounds from propargyl acetates or vinyl allenes involving up to three Au(I)-catalyzed elemental steps: 3,3-rearrangement, metalla-Nazarov reaction, and electrophilic cyclopropanation. The reaction proceeds under very mild conditions and in short times. The mechanism has been studied by DFT computations.
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