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. 2007 May 11;21(8):1043-5.
doi: 10.1097/QAD.0b013e3280d5a7ac.

Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

Aurelia Lamine  1 , Anne Caumont-Sarcos, Marie-Laure Chaix, Asier Saez-Cirion, Christine Rouzioux, Jean-François Delfraissy, Gianfranco Pancino, Olivier Lambotte
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Replication-competent HIV strains infect HIV controllers despite undetectable viremia (ANRS EP36 study)

Aurelia Lamine et al. AIDS. .

Abstract

The replicative potential of HIV-1 strains in a well-characterized group of eight HIV controllers was investigated. Replication-competent viruses were detected in CD4 T-cell co-culture supernatants from all HIV controllers. The phylogenetic analysis of C2V4 suggested viral evolution or co-infection or superinfection in two out of the four patients analysed. The vif and vpr genes were normal. Infection with HIV-1 variants with attenuated replicative capacity cannot be a general factor accounting for undetectable viraemia in HIV controllers.

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