doi: 10.1097/QAD.0b013e32810c8caa.
Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control
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- PMID: 17457102
- DOI: 10.1097/QAD.0b013e32810c8caa
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Relationship between serum IL-7 concentrations and lymphopenia upon different levels of HIV immune control
AIDS.
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Abstract
Serum IL-7 levels correlate with T-cell depletion in HIV-infected individuals. In some patients, we observed that serum IL-7 decreases upon progression to AIDS, suggesting a role for IL-7 in T-cell maintenance in sporadic cases. Interestingly, IL-7 levels were significantly lower in stable long-term non-progressors (LTNP) than in patients who lost the LTNP status in a 3-year follow-up (P < 0.001), indicating that the serum IL-7 concentration might be a valuable marker for maintenance of the LTNP state.
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