Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Comparative Study
. 1991 Sep;82(9):443-8.

[Clinico-pathological evaluation of patients with homozygous familial hypercholesterolemia]

[Article in Italian]
F P D'Armiento  1 , F Di Gregorio, C Napoli, P Colasanti, T Posca, A Calì
Affiliations
  • PMID: 1745828
Comparative Study

[Clinico-pathological evaluation of patients with homozygous familial hypercholesterolemia]

[Article in Italian]
F P D'Armiento et al. Recenti Prog Med. 1991 Sep.

Abstract

The authors have studied 8 patients with Homozygous Familial Hypercholesterolemia (FHO) an autosomal genetic dominant disease due to mutation of the gene encoding a cell surface receptor for LDL. Anatomic and pathologic abnormalities caused by LDL-cholesterol and B-Apolipoprotein high plasma levels were found. We also measured malondialdehyde levels in plasma and atherosclerotic plaques of the only autoptic case observed. MDA-levels are an index of lipid peroxidation. Cutaneous xanthomatosis lesions and severe cardiovascular disease were also present.

PubMed Disclaimer