Review
doi: 10.1007/s10555-007-9063-1.
Hypoxia, gene expression, and metastasis
Affiliations
- PMID: 17458506
- DOI: 10.1007/s10555-007-9063-1
Item in Clipboard
Review
Hypoxia, gene expression, and metastasis
Cancer Metastasis Rev.
2007 Jun.
Abstract
Hypoxia poses many problems to the treatment of cancer. Hypoxic tumors are more resistant to chemotherapy and radiation. In addition, hypoxia induces a number of genes responsible for increased invasion, aggressiveness, and metastasis of tumors. The augmented metastatic potential due to hypoxia-mediated gene expression is discussed in this section. Particular attention is given to recent studies of specific genes involved in the key steps of metastasis, including extracellular matrix interactions, migration, and proliferation.
Similar articles
-
MUC1 enhances hypoxia-driven angiogenesis through the regulation of multiple proangiogenic factors.Oncogene. 2013 Sep 26;32(39):4614-21. doi: 10.1038/onc.2012.478. Epub 2012 Oct 29. Oncogene. 2013. PMID: 23108411
-
Hypoxic gene expression and metastasis.Cancer Metastasis Rev. 2004 Aug-Dec;23(3-4):293-310. doi: 10.1023/B:CANC.0000031768.89246.d7. Cancer Metastasis Rev. 2004. PMID: 15197330 Review.
-
Both macrophages and hypoxia play critical role in regulating invasion of gastric cancer in vitro.Acta Oncol. 2013 May;52(4):852-60. doi: 10.3109/0284186X.2012.718444. Epub 2012 Nov 29. Acta Oncol. 2013. PMID: 23193956
-
Increased expression of EIF5A2, via hypoxia or gene amplification, contributes to metastasis and angiogenesis of esophageal squamous cell carcinoma.Gastroenterology. 2014 Jun;146(7):1701-13.e9. doi: 10.1053/j.gastro.2014.02.029. Epub 2014 Feb 21. Gastroenterology. 2014. PMID: 24561231
-
CCN proteins and cancer: two to tango.Front Biosci. 2005 May 1;10:998-1009. doi: 10.2741/1594. Front Biosci. 2005. PMID: 15769600 Review.
Cited by
-
Inhibitory effects of dieckol on hypoxia-induced epithelial-mesenchymal transition of HT29 human colorectal cancer cells.Mol Med Rep. 2016 Dec;14(6):5148-5154. doi: 10.3892/mmr.2016.5872. Epub 2016 Oct 21. Mol Med Rep. 2016. PMID: 27779676 Free PMC article.
-
Targeting oncogenic serine/threonine-protein kinase BRAF in cancer cells inhibits angiogenesis and abrogates hypoxia.Proc Natl Acad Sci U S A. 2012 Feb 7;109(6):E353-9. doi: 10.1073/pnas.1105026109. Epub 2011 Dec 27. Proc Natl Acad Sci U S A. 2012. PMID: 22203991 Free PMC article.
-
SETDB-1: A Potential Epigenetic Regulator in Breast Cancer Metastasis.Cancers (Basel). 2019 Aug 9;11(8):1143. doi: 10.3390/cancers11081143. Cancers (Basel). 2019. PMID: 31405032 Free PMC article. Review.
-
Regulation of the histone demethylase JMJD1A by hypoxia-inducible factor 1 alpha enhances hypoxic gene expression and tumor growth.Mol Cell Biol. 2010 Jan;30(1):344-53. doi: 10.1128/MCB.00444-09. Mol Cell Biol. 2010. PMID: 19858293 Free PMC article.
-
The Critical Role of Hypoxic Microenvironment and Epigenetic Deregulation in Esophageal Cancer Radioresistance.Genes (Basel). 2019 Nov 14;10(11):927. doi: 10.3390/genes10110927. Genes (Basel). 2019. PMID: 31739546 Free PMC article. Review.
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources
Other Literature Sources
