Analysis of HIV-1 CRF07_BC gag p6 sequences indicating novel deletions in the central region of p6

Abstract

We amplified gag sequences from 66 individuals infected with HIV-1 CRF07_BC during 2003-2005 in the Xinjiang region of China. A novel deletion of 7aa (including a KELY motif) in the central region of the CRF07_BC gag p6 domain was detected, which has not been reported in other HIV-1 subtypes. Further deletions of up to 13aa (including KQE and KELY motifs) was also found in this domain, representing the biggest natural deletion up to now. Moreover, the CD4+ count and viral load level indicated that 1-13aa deletions in CRF07_BC gag p6 do not have a significant effect on viral replication and fitness.