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Comment
. 2007 Apr;26(4):383-5.
doi: 10.1016/j.immuni.2007.04.005.

A signal for the caspase-1 inflammasome free of TLR

Charles A Dinarello  1
Affiliations
Free article
Comment

A signal for the caspase-1 inflammasome free of TLR

Charles A Dinarello. Immunity. 2007 Apr.
Free article

Abstract

Secretion of the proinflammatory cytokine IL-1beta requires caspase-1 and Toll-like receptor (TLR) signaling. However, Kanneganti et al. (2007) find that bacteria can use pore-forming mechanisms to activate caspase-1 for the production of IL-1beta precursor independently of TLRs.

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