Review
doi: 10.1016/j.immuni.2007.04.003.
The final touches make perfect the peptide-MHC class I repertoire
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- PMID: 17459809
- DOI: 10.1016/j.immuni.2007.04.003
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Review
The final touches make perfect the peptide-MHC class I repertoire
Immunity.
2007 Apr.
Free article
Abstract
Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8(+) T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.
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