Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2007 Apr;26(4):397-406.
doi: 10.1016/j.immuni.2007.04.003.

The final touches make perfect the peptide-MHC class I repertoire

Gianna Elena Hammer  1 , Takayuki Kanaseki, Nilabh Shastri
Affiliations
Free article
Review

The final touches make perfect the peptide-MHC class I repertoire

Gianna Elena Hammer et al. Immunity. 2007 Apr.
Free article

Abstract

Major histocompatibility complex (MHC) class I molecules present short, perfectly cleaved peptides on the cell surface for immune surveillance by CD8(+) T cells. The pathway for generating these peptides begins in the cytoplasm, and the peptide-MHC I (pMHC I) repertoire is finalized in the endoplasmic reticulum. Recent studies show that the peptides for MHC I are customized by the ER aminopeptidase associated with antigen processing and by dynamic interactions within the MHC peptide-loading complex. Failure to customize the pMHC I repertoire has profound immunological consequences.

PubMed Disclaimer

Publication types

MeSH terms

Substances

LinkOut - more resources