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Review
. 2007 Jul;81(13):6777-84.
doi: 10.1128/JVI.00153-07. Epub 2007 Apr 25.

Epstein-barr virus: environmental trigger of multiple sclerosis?

Jan D Lünemann  1 , Thomas Kamradt, Roland Martin, Christian Münz
Affiliations
Review

Epstein-barr virus: environmental trigger of multiple sclerosis?

Jan D Lünemann et al. J Virol. 2007 Jul.
No abstract available

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Figures

FIG. 1.
FIG. 1.
Potential mechanisms responsible for the association of EBV infection with MS. (1) EBV-specific T cells or antibodies could cross-react with autoantigens expressed in the CNS and attack the myelin sheath of axons. (2) Latent EBV antigens could sustain the survival of autoreactive B cells. (3) EBV infection transactivates retroviral elements such as HERVs, which in turn mediate cell death of oligodendrocytes. (4) Autoreactive B-cell activation could initiate EBV replication and in turn augment EBV-specific T- and B-cell responses.
See this image and copyright information in PMC

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