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Review
. 2007 Mar;27(3):269-75.
doi: 10.1097/IAE.0b013e31802e3e9b.

Role of genetic factors and inflammation in age-related macular degeneration

Darius M Moshfeghi  1 , Mark S Blumenkranz
Affiliations
Review

Role of genetic factors and inflammation in age-related macular degeneration

Darius M Moshfeghi et al. Retina. 2007 Mar.

Abstract

Complement factor H (CFH) has been implicated in the predisposition to advanced forms of age-related macular degeneration (AMD). The purpose of this review is to highlight recent discoveries implicating single nucleotide polymorphisms on 1q32, 6p21, and 10q26 in the risk for development of AMD. In addition, the central role of CFH in the complement cascade and its role in the inflammatory hypothesis for AMD are reviewed.

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