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Review
. 2007 Mar 14;13(10):1500-4.
doi: 10.3748/wjg.v13.i10.1500.

Multi-disciplinary treatment for cholangiocellular carcinoma

Mitsugi Shimoda  1 , Keiichi Kubota
Affiliations
Review

Multi-disciplinary treatment for cholangiocellular carcinoma

Mitsugi Shimoda et al. World J Gastroenterol. .

Abstract

Cholangiocarcinoma (CC) is rare malignant tumors composed of cells that resemble those of the biliary tract. It is notoriously difficult to diagnose, and is associated with a high mortality. Traditionally, CC is divided into intrahepatic and extrahepatic disease according to its location within the biliary tree. Intrahepatic cholangiocellular carcinoma (IH-CCC) or peripheral cholangiocellular carcinoma (CCC) appears within the second bifurcation of hepatic bile duct, and is the second most common primary liver cancer following hepatocellular carcinoma (HCC), IH-CCC or peripheral CCC often presents with advanced clinical features, and the cause for this cancer rise is still unclear. MRI, CT and PET provide useful diagnostic information in those patients. Surgical resection is the only chance for cure, with results depending on selected patients and careful surgical technique. Liver transplantation could offer long-term survival in selected patients when combined with chemotherapy. Chemotherapy, radiation therapy or combination therapies remain as the only treatment for inoperable patients. However, these are uniformly ineffective in patients' survival.

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Figures

Figure 1
Figure 1
Makuuchi craiteria.
Figure 2
Figure 2
Surgical management of IH-CCC.
Figure 3
Figure 3
Actuarial patients survival calculated by using Kaplan-Meier methods at 1, 3 and 5 years after surgery for IH-CCC.
Figure 4
Figure 4
Actuarial patients survival calculated by using Kaplan-Meier methods at 1, 3 and 5 years after R0 versus R1 resection for IH-CCC.
See this image and copyright information in PMC

References

    1. Yeo CJ, Pitt HA, Cameron JL. Cholangiocarcinoma. Surg Clin North Am. 1990;70:1429–1447. - PubMed
    1. Rossi RL, Heiss FW, Beckmann CF, Braasch JW. Management of cancer of the bile duct. Surg Clin North Am. 1985;65:59–78. - PubMed
    1. Altemeier WA, Gall EA, Zinninger MM, Hoxworth PI. Sclerosing carcinoma of the major intrahepatic bile ducts. AMA Arch Surg. 1957;75:450–460; discussion 460-461. - PubMed
    1. Klatskin G. Adenocarcinome of the hepatic duct at its bifucation within the porta hepatic. An unusual tumor with distinctive clinical and pathological features. Am J Med. 1965;38:241–256. - PubMed
    1. Liver cancer study group of Japan. The general rules for the clinical and pathological study of primary liver cancer. Tokyo: Kanehara; 2000. - PubMed