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Comparative Study
. 2007 Mar 14;13(10):1585-94.
doi: 10.3748/wjg.v13.i10.1585.

Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study

Lesley A Anderson  1 , R G Peter Watson, Seamus J Murphy, Brian T Johnston, Harry Comber, Jim Mc Guigan, John V Reynolds, Liam J Murray
Affiliations
Comparative Study

Risk factors for Barrett's oesophagus and oesophageal adenocarcinoma: results from the FINBAR study

Lesley A Anderson et al. World J Gastroenterol. .

Abstract

Aim: To investigate risk factors associated with Barrett's oesophagus and oesophageal adenocarcinoma.

Methods: This all-Ireland population-based case-control study recruited 224 Barrett's oesophagus patients, 227 oesophageal adenocarcinoma patients and 260 controls. All participants underwent a structured interview with information obtained about potential lifestyle and environmental risk factors.

Results: Gastro-oesophageal reflux was associated with Barrett's [OR 12.0 (95% CI 7.64-18.7)] and oesophageal adenocarcinoma [OR 3.48 (95% CI 2.25-5.41)]. Oesophageal adenocarcinoma patients were more likely than controls to be ex- or current smokers [OR 1.72 (95% CI 1.06-2.81) and OR 4.84 (95% CI 2.72-8.61) respectively] and to have a high body mass index [OR 2.69 (95% CI 1.62-4.46)]. No significant associations were observed between these risk factors and Barrett's oesophagus. Fruit but not vegetables were negatively associated with oesophageal adenocarcinoma [OR 0.50 (95% CI 0.30-0.86)].

Conclusion: A high body mass index, a diet low in fruit and cigarette smoking may be involved in the progression from Barrett's oesophagus to oesophageal adenocarcinoma.

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References

    1. Ruol A, Parenti A, Zaninotto G, Merigliano S, Costantini M, Cagol M, Alfieri R, Bonavina L, Peracchia A, Ancona E. Intestinal metaplasia is the probable common precursor of adenocarcinoma in barrett esophagus and adenocarcinoma of the gastric cardia. Cancer. 2000;88:2520–2528. - PubMed
    1. Hansson LE, Sparén P, Nyrén O. Increasing incidence of both major histological types of esophageal carcinomas among men in Sweden. Int J Cancer. 1993;54:402–407. - PubMed
    1. Botterweck AA, Schouten LJ, Volovics A, Dorant E, van Den Brandt PA. Trends in incidence of adenocarcinoma of the oesophagus and gastric cardia in ten European countries. Int J Epidemiol. 2000;29:645–654. - PubMed
    1. Powell J, McConkey CC. The rising trend in oesophageal adenocarcinoma and gastric cardia. Eur J Cancer Prev. 1992;1:265–269. - PubMed
    1. Møller H. Incidence of cancer of oesophagus, cardia and stomach in Denmark. Eur J Cancer Prev. 1992;1:159–164. - PubMed

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