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. 2007 Apr 27;316(5824):604-8.
doi: 10.1126/science.1141229.

Regulation of the germinal center response by microRNA-155

To-Ha Thai  1 , Dinis Pedro Calado, Stefano Casola, K Mark Ansel, Changchun Xiao, Yingzi Xue, Andrew Murphy, David Frendewey, David Valenzuela, Jeffery L Kutok, Marc Schmidt-Supprian, Nikolaus Rajewsky, George Yancopoulos, Anjana Rao, Klaus Rajewsky
Affiliations

Regulation of the germinal center response by microRNA-155

To-Ha Thai et al. Science. .

Abstract

MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.

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