doi: 10.1039/b702481a.
Epub 2007 Mar 23.
Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin
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- PMID: 17464412
- DOI: 10.1039/b702481a
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Design and total synthesis of unnatural analogues of the sub-nanomolar SERCA inhibitor thapsigargin
Org Biomol Chem.
.
Abstract
Thapsigargin is a densely oxygenated guaianolide which displays potent sarco/endoplasmic reticulum Ca(2+) ATPase (SERCA) binding affinities. The total syntheses of designed unnatural analogues of this important natural product are described. This article constitutes the chemical synthesis behind an ongoing project. Rational modifications have been made to the lactone region of thapsigargin in order to obtain derivatives for future structure-activity relationship studies.
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